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In most cases, no cause for IGHD can be identified; however, the proportion of idiopathic IGHD cases may be decreasing due to identification of causative factors.

The phenotype of IGHD is variable depending in part on the underlying genetic disorders in the affected individuals.

US Medical Division, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 5015, Indianapolis, IN, 46285, USA, [email protected]

First, IGF-I synthesis is not only regulated by GH but also by nutrient supply and by other hormones; second, low IGF-I levels in the presence of normal or increased GH secretion may reflect a peripheral resistance to GH action.

IGF-I measurements in the diagnosis of adult growth hormone deficiency. There are two main limitations in the clinical use of IGF-I levels as a marker of GH secretion.

Although serum insulin-like growth factor I (IGF-I) concentrations have utility as a screening test for growth hormone (GH) deficiency in children and young adults, they are less accurate for screening in adults over 40 years of age.

Compared to placebo rapid-eye-movement sleep decreased during the first half of the night after 4x25mug GHRH and sleep stage 4 decreased after 4x50mug GHRH. Bartholomew’s and the Royal London Hospitals, QM, University of London, London, UK.Validation of growth-hormone-releasing peptide 2 for the diagnosis of adult growth hormone deficiency. However, this clinical sub-categorization of IGHD may need reconsideration due to the recent identification of molecular heterogeneity within each sub-type of IGHD.In a small number of children with IGHD, defects in the GH, GH-releasing hormone receptor (GHRH-R), and GH1 genes have been identified.In addition, 12 patients had the femoral neck BMD examined.In 10 cases, bone scintigraphy using 99-technetium labeled methylene diphosphonate was performed.

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